Plugging Holes

Plugging the holes in hepatitis C virus antiviral therapy.

A growing number of RNA viruses are now known to depend on virus-encoded ion channels for efficient production of infectious virions and, in some cases, for the subsequent infection of naı̈ve cells. So-called viroporins are small hydrophobic proteins, usually less than 100 aa in length, and typically contain 1 or 2 transmembrane domains (TMDs); oligomerization is therefore necessary for the form...

Plugging (publicising) to prevent mucous plugging.

Plugging the Holes in Water Distribution Systems: Deficiencies May Contribute to Gastrointestinal Illnesses

Deficiencies in drinking water distribution systems can result in illness, even if the water meets health standards as it leaves a treat­ ment facility. A new review in EHP discusses the routine malfunc­ tions in distribution networks that contribute to background levels of gastrointestinal illness and highlights critical research needs. The most common adverse health effects from unsafe drinki...

Plugging the Gap

Normal saline and mucous plugging.

cialist in the medical critical care/pulmonary unit at Christiana Care Health System in Newark, Delaware. history of smoking along with chronic respiratory diseases such as cystic fibrosis, chronic obstructive pulmonary disease, asthma, and bronchiectasis. Other patient-related factors that may contribute include smoking, immobility, sedation, muscle weakness, and dehydration. A mucous plug occ...